Refitting the Hill curve led to a steepness coefficient of 2.3, which we updated in the main text (subsection "NF-κB switch dynamics distinguish pathogen (LPS) and host (TNF) signals").
To estimate the conditioning voltage when the subsequent peak Na+ current is half maximally inactivated, the data points can be fitted to the equation: (1) Here h∞ is the relative Na+ current, Vh is the voltage when the Na+ channels are half maximally inactivated (h∞ = 0.5) and kh is the steepness coefficient.
The effects of the wave steepness, the blockage coefficient of perforated wall and the relative wave chamber width on the reflection coefficient are clarified.
The models predict the relative scour depth (Smax/H0) on the basis of the following variables: relative water depth at the toe of the breakwater (htoe/L0), Shields parameter, non-breaking wave steepness (H0/L0), and reflection coefficient (Cr).
The top six most sensitive parameters to the river discharge were the groundwater delay factor (GW_DELAY), average slope steepness (HRU_SLP), groundwater "revap" coefficient (GW-REVAP), available water content of the soil (SOL_AWC), average slope length (SLSUBBSN), and the curve number (CN_2) (Fig. 10).
Across five variants of the network, steepness tuning with Hill coefficients ranging from n∼2 to 20 was observed accompanied by changes in vertical extension.
The parameter n (the "Hill" coefficient) affects the "steepness" of the concentration effect relationship.
An ideal titratable system would exhibit uniform expression across the cell population at all inducer concentrations, a large dynamic range, a low inducer concentration to achieve half-maximal induction, and a low Hill coefficient reflecting the steepness of the response curve.
Such E max -models are based on three key PD parameters: maximum growth rate, i.e., growth without antimicrobial pressure, drug concentration leading to a half-maximum effect (EC50); and the Hill's coefficient, describing the steepness of a sigmoid Hill equation [ 9, 10].
Here, V denotes reaction velocity, Vmax the maximal velocity, x the substrate concentration, Km the substrate concentration where half-maximal velocity is reached and h, the Hill-coefficient, represents the steepness of the response.
In contrast, the Hill coefficients, capturing the steepness of response to tetracycline, were smaller for susceptible strains than resistant strains (P < 0.00001; Fig. 3c), showing that the susceptible strains were more affected by low concentrations of drugs than resistant ones.
