The penalties for not filing are steep (if you owe money) and build over time.
If there is neutral mixing, steep gradients in allele frequencies will decay over time resulting in wide, shallow clines; conversely, if there is a strong barrier to gene flow because of selection against hybrids and/or assortative mating, steep clines may be maintained [ 2, 10, 39].
Additionally, PON1 polymorphisms modify the effect of age on enzyme activity such that some children experience much steeper increases over time than others.
Five-day BNP kinetics demonstrated a significantly steeper decline over time in septic shock patients than in severe sepsis or hemorrhagic shock patients.
So while guideline-consistent laboratory tests showed a much steeper increase over time, the other laboratory tests continued to represent the more significant share of total expenditure, even at the end of the period.
Estimated rates of TKR increased more sharply in females than in males, and the observed rates of primary TKR also showed a steeper increase over time in females than males; patterns that plausibly reflect the greater prevalence of OA in women compared with men.
To address this concern, we have performed additional adoptive transfer experiments of peripheral T cells using the Rag1-GFP reporter system, and found that blt/ blt Rag1-GFP+ T cells underwent a steeper decline over time compared to control blt/+ Rag1-GFP+ T cells.
Using a population-based approach, data from a 3-year follow-up of a randomly selected stratified sample of community-dwelling older persons at risk of functional decline with a longitudinal quasi-experimental design, we found that living in experimental area identified for implementation of an ISD network was associated with initially more unmet needs, but also with a steeper decrease over time.
Recently, data from 405 children in the Gateshead Millenium project demonstrated that physical activity showed the steepest decline over time in children with higher BMI [30].
