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Exact(15)
As our system was rather suitable for the semiquantitative "YES/NO" applications due to the steep response curve, an alternative circuitry for widening the linear range was also probed.
We observed a very steep response over a small concentration range of indole, which is indicative of biological significance for odor binding to an OBP.
The steep response curves we observed in the FlashPlate assays are indicative of a cooperative ligand binding and therefore may represent the binding of indole to AgamOBP1 dimers and/or trimers [43].
Rather, it is a generic feature of GRNs with steep response functions.
Xanafide exhibited a steep response curve in all four cell lines tested.
By contrast with DAS28 CRP), simulations exploring the dose-response surface for ACR20 revealed a steep response curve.
Similar(45)
The CVs of the regulating genes are significantly smaller than for the unregulating gene, in particular for steep responses.
This analysis pertains to the limiting case of very steep responses functions, but is approximately valid when the response is more gradual.
This situation is sometimes desired to create switches with steep responses [ 32], but when the input device is affected by large-entity noise at low-induction levels the NOT gate could propagate and amplify this noise and the transfer function parameters of the NOT gate, estimated from central tendency measures, would also be affected.
For example, a sharper (nonlinear) increase of the kinase in Figure 2D leads to steeper response curves of the total and non-degradable substrate, compared to the linear kinase increase in Figure 2C.
If the direction of the steepest response reduction is consistent in the parameter space, the ratio should be similar between the two comparisons.
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