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However, highly conformal treatment techniques commonly establish steep dose gradients between tumor and avoidance structures.
A potential alternative is treatment with a broadband 50kV X-ray point source, the advantage being its low energy and the consequential steep dose gradient.
MOSkins are MOSFET dosimeters designed and developed at the Centre for Medical Radiation Physics Universityy of Wollongong, Australia), optimized to measure the dose in steep dose gradients.
Those can provide an adequate dose rate, energy spectrum and a minimal beam divergence, allowing the deposition of the steep dose gradients between MBs.
The steep dose fall close to the target periphery demands high precision in the treatment delivery.
Charged particles provide the physical advantage of an inverted dose profile which enables steep dose gradients.
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These effects exhibited a steep dose-response curve.
In both the cynomolgus monkey and in the rat studies, a steep dose-effect relationship for PFOS was conspicuous.
This reduction may be particularly important for clinical application as steep dose-response might pose challenges in cases of low compliance and unfavorable pharmacokinetic profile [22].
Further, the innate immune response and antitumor activity both displayed an unusually steep dose-response curve and were not accompanied by antiangiogenesis.
However, doses of GHB are difficult to calibrate as it is highly potent with a steep dose-response curve, and co-using GHB with alcohol increases its effects.
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