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Classical theoretical models predict that autonomous elements can be present in the genomes of a population as long as their steady transposition rates can counterbalance their elimination by natural selection [ 2, 3].
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The steady-state rate of transposition was reduced in proportion to the binding affinity of the transposase.
The values of the kinetic parameters determine the magnitude of the steady-state rate of transposition as well as the copy number at which it is achieved.
When the calculated diffusion rates are applied in the computer model, a pseudo-steady-state rate of transposition is established when there are about 200 copies of the transposon.
ME transposition generates a steady stream of polymorphic genetic markers, deleterious and adaptive mutations, and substrates for further genomic rearrangements.
Once a certain number of copies of the transposon are established in the genome, and the transposase concentration is above a critical threshold, the mechanism provides a steady-state rate, perfectly damping the exponential amplification which is a natural consequence of unregulated transposition.
The transposition is complete.
The result was a political transposition.
First steady.
Very steady.
Steady, guys.
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