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SBI-087 clearance (IV) ranged from 22 to 229 mL/h; volume of distribution at steady state ranged from 5 to 12 L. Apparent clearance (SC) ranged from 44.7 to 105 mL/h; volume of distribution ranged from 14.3 to 32.1 L. Overall, PK properties were similar at equivalent doses between IV/SC administrations in patients with RA/SLE.
After oral administration of vesicare to healthy volunteers, peak plasma levels (Cmax) of Solifenacin reached within 3 to 8 h after administration and at steady state ranged from 32.3 to 62.9 ng/mL for the 5 and 10 mg vesicare tablets, respectively.
Volume of distribution at steady state ranged between 8 and 16 L/m, nominally equivalent to the extracellular fluid volume.
The mean volume of distribution at a steady state ranged from between 43 and 83 mL/kg for the three ALX-0061 dosuggestingsthat that drug distribution is limited to the vascular and extracellular space, as generally described for monoclonal antibodies [ 25].
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Fulvestrant was subject to extensive and rapid distribution, with estimates of the volume of distribution (Vss) at the steady state ranging from 3.0 to 5.3 l kg−1.
In the quasi-steady state range and over the entire range of testing temperatures and stresses, the minimum creep rate, ε̇min, is given by:ε̇min(s−1)=ε̇0·exp[19±1]· σ/σ0 1.5±0.1·exp −445±10) kJ/molRTwhere σ0=MPa and ε̇0=1 s−1.
In contrast, our p53-AKT model exhibits sustained oscillations around the low-p53 steady state in both single-steady state and multiple-steady state ranges of parameters (Figure 2); furthermore, these oscillations arise out of supercritical Hopf bifurcation.
Mean residence times ranged from 1.35 to 7.2 hr; steady state conversions ranged from 15 to 61%.
For treatment cycles 1 and 3, the mean AUC (0– tlast) was between 153 and 157 ng h−1 ml−1, the mean terminal elimination half-life (t1/2) ranged from 33 to 58 h, the mean total body clearance was between 1000 and 1359 ml min−1, and the mean volume of distribution at steady state (Vss) ranged from 1851 to 4852 l (Table 4).
The time domain is divided into the transient range and the steady-state range.
In the interstitia, diurnal ranges of VEGF and sVEGFR1 were much subdued compared to steady-state ranges: free VEGF varied up to 0.2 pM (∼2% about controls), with negligible effects on VEGF-VEGFR complex formation; while free sVEGFR1 varied up to 2.5 pM (∼7% about controls).
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