Sentence examples for steady state exposures from inspiring English sources

The chronic exposure estimates are more robust and representative of typical and steady state exposures.

In this study, three month old female Tg2576 mice (n = 20 per group) were administered SPI-1865 for six days, which is sufficient to reach steady state exposures based on previous murine pharmacokinetic analysis (data not shown).

Therefore, population central tendency concentrations are more likely representative of long-term average exposures and are more appropriately compared to biomonitoring guidance values based upon chronic toxicity benchmarks that assume long-term steady state exposure (Hays et al., 2012; Kirman et al., 2012).

With a 5-fold increase in dose, the steady-state exposures for silybin A and silybin B increased 11-fold and 38-fold, respectively, suggesting non-linear pharmacokinetics.

Pharmacokinetic differences between short-term and steady-state exposures may also include differences in saturation of induction and metabolite generation.

Additionally, it has recently been hypothesized that blood levels may provide a better dosimeter than urinary levels for steady-state exposures (Needham 2005).

Consistently, tocilizumab concentrations over time and steady-state exposures were numerically lower in the 8 mg/kg less than 30 kg group than in the other two groups (see online supplementary table S2, supplementary figure S1A).

Only a weak correlation was observed between creatinin clearance and steady-state exposure.

No evidence of drug accumulation was observed, and the steady-state exposure plateaued at 800 mg daily.

Bone lead concentrations are a better measure of cumulative exposure to lead, although there is a correlation between the two in "steady-state" exposure (Cheng et al. 1998).

In both age groups, it took 2 3 days to reach steady-state exposure, and thereafter the total exposure of IDeg was unchanged from day to day.