Sentence examples for steady state exposure from inspiring English sources

Therefore, population central tendency concentrations are more likely representative of long-term average exposures and are more appropriately compared to biomonitoring guidance values based upon chronic toxicity benchmarks that assume long-term steady state exposure (Hays et al., 2012; Kirman et al., 2012).

The chronic exposure estimates are more robust and representative of typical and steady state exposures.

In this study, three month old female Tg2576 mice (n = 20 per group) were administered SPI-1865 for six days, which is sufficient to reach steady state exposures based on previous murine pharmacokinetic analysis (data not shown).

Only a weak correlation was observed between creatinin clearance and steady-state exposure.

No evidence of drug accumulation was observed, and the steady-state exposure plateaued at 800 mg daily.

Doses of buparlisib ≥50 mg/day led to steady-state exposure levels ≥10 000 ng*h/mL, which are estimated to be efficacious based on preclinical studies.

Bone lead concentrations are a better measure of cumulative exposure to lead, although there is a correlation between the two in "steady-state" exposure (Cheng et al. 1998).

The relatively small within-worker differences in daily urinary TCPy levels throughout the study suggest that these workers were approaching a steady-state exposure to CPF.

12 Denosumab clearance is proportional to body weight, with steady-state exposure higher in lower weight individuals compared with higher weight individuals.

13 Fluconazole and voriconazole are inhibitors of CYP3A, CYP2C9, and CYP2C19, and coadministration with etravirine resulted in a slight increase in etravirine steady-state exposure.

The effects of impaired renal function on the steady-state exposure of dapagliflozin and D3OG were realized by calculating the AUCss using Eqs.