Sentence examples similar to steady state dose from inspiring English sources

The potential association between CYP3A5*3, CYP3A4*22, PPARA, POR*28 genotypes and steady state dose-adjusted Tac C0 (C0/D, μg*L-1/mg) or CsA C2 (C2/D, μg*L-1/mg) concentration, 2 7 weeks post-transplantation was investigated.

However because of the long half-life of aminoglycosides in neonates this once daily regimen is more like steady state dosing achieved by 8 hourly dosing in adults.

Ultrasensitivity in the steady-state dose response of αf versus total MazF (mazFT=2 × [pf]ss+2 × [rf]ss+2 × [ff]ss+2 × [fe]ss+2 × [mazFpd]ss+2 × [cef]ss+[mazFp]ss) was moderately enhanced by up to ∼23% in a narrow parameter regime corresponding to high KDf and intermediate αe values, presumably via molecular sequestration (Supplementary Fig. 16d 24.

The increase in ultrasensitivity of the dose response of mazFT versus λ as a function of KDf (Fig. 4d) qualitatively reflected the enhanced ultrasensitivity of the steady-state dose response of aTc versus biomass (OD600) for cells expressing MazF-P compared to MazF-U (Supplementary Fig. 10b).

However, Schalekamp et al. observed a 3.7-mg lower weekly phenprocoumon steady-state dose for CYP2C9*2 carriers and a 4.4-mg lower weekly dose for CYP2C9*3 carriers compared with wild-type carriers [ 36].

However, these solutions did not appreciably change the steady-state dose responses (data not shown), indicating that under these conditions and model parameters, reaction rate fluctuations do not constitute a significant source of signaling variability.

Therefore, the aim of our study was to investigate the impact of SNPs in these genes (VKORC1 c.-1639G>A c.-1639G>A, CYP2C9 *3, CYP2C9 CYP4F2G>A, CALU c.*4A>G, EPHX1 c.337T>C, F7 c.-402G>A, F7 c.-401G>T, GGCX c.214+597G>A, PROC c.-228C>T and PROC c.-215G>A) on the phenprocoumon steady-state dose and to develop a formula to predict the effective phenprocoumon maintenance dose.

Steady-state dose-response relationships, current-voltage relationships, ionic selectivities, and single-channel properties were recorded using voltage-clamp techniques.

Plasma samples were obtained following the loading and steady-state doses (doses 3-5).

Most studies look at the steady-state dose-response of the average phosphorylated substrate versus the kinase-phosphatase balance (K t / P t ).

In this paper, we have studied the steady-state dose-response in basic PDC motif and a modified PDC motif using analytical and numerical methods.