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A comparison between the steady state assumption [Miralles-Wilhelm, F., Gelhar, L.W., Kapoor, V., 1997.
The GFA is based on a constraint-based modeling of the glycosylation network, employing a pseudo steady state assumption.
In contrast to similar approaches in the literature, the here presented approach does not require a steady state assumption.
If the CheR variation is too fast, the steady state assumption is violated and we expect deviations.
The quasi steady state assumption for complex C leads then to the Michaelis-Menten kinetic law.
In some cases, the steady state assumption makes obvious sense based on biological reasoning.
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One way to address this is to apply a stochastic quasi-steady state assumption.
This is the same as the Michaelis-Menten pseudo-steady state assumption [ 9].
(B) The same quasi-steady state assumption is, for the reasons outlined above, made use of in the remaining models.
As explained above, we can "soften" the model-based constraints to relax the pseudo-steady state assumption.
The stoichiometric relationships among the metabolites and the reactions of the E. coli genome-scale metabolic model were balanced under the pseudo-steady state assumption.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com