As a potential vaccine candidate, VLP vaccines have many advantages, such as remarkable immunogenicity, safety, steady, and presentation of foreign antigens (Crisci et al. 2012).
In the steady state, presentation of these self-antigens should sustain tolerance.
The stimulus s from Equation 12 uses a sine signal as a basis for stimulating both the noise reduction subsystem as well as the transient noise reduction subsystem: while a steady-state presentation of the sine signal would be sufficient for triggering the noise reduction, the dramatic change of the sine amplitude at time T1 is required to trigger the transient noise reduction.
Anything but a steady and meaningful presentation of what this league used to do best, the game itself, for which a series of rule changes now follows every ratings downturn, the latest and most radical going into effect next season without even a trial run.
The reduced susceptibility of the SDE T5 to tolerance induction likely reflects the relatively short half-life of T5/Db complexes 20, 30, resulting in diminished steady-state epitope presentation levels and a failure to induce negative selection 27.
In vivo, under steady-state conditions, presentation by splenic DC of apoptotic cell-derived peptides loaded in MHC class-I or -II molecule leads to clonal deletion of Ag-specific CD8 or CD4 T cells, respectively, and generation of Ag-specific regulatory T cells (Treg) [ 55– 58].
The basic paradigm for peptide-induced tolerance in naive T cells is that antigen presentation by steady state DC leads to an abortive activation and T cell death due to insufficient survival signals [ 12].
The mean age of presentation shows a steady increase from 41.1 to 45.6 years from 2005 -2010.
He helped salesmen perfect their pitch and businessmen steady their nerves before a big presentation; he taught his students how to summon courage when they were nervous and feign confidence when they were sick with terror.
Prior to clinical presentation there is a steady exponential rise (with a typical doubling time of around 30 days) in AFP levels.
