Tenthoff says this Byzantine arrangement is good for the company because it makes it clear to investors that the higher-risk work being done by the Genzyme divisions is separate from the steady, dependable niche-drug development that has kept Genzyme in the top ranks of biotechs.
Improved manufacturing systems will allow the bigger carmakers to offer an ever wider range of models, supplemented by a steady stream of niche products from new entrants.
With Macs holding steady as a beloved niche product at around 10% of their income, it's notable that services, such as the App Store and Apple Pay, made almost as much for Apple as selling Macs did this last quarter.
A contrasting model has also been proposed, in which HSCs would be found in a relatively fluid equilibrium between endosteal and vascular niches at steady state and preferentially localize to the endosteal niche after injury due to irradiation [40], [42].
In a career spanning more than two decades, Chris Penn carved a niche for himself as a steady, journeyman actor, finding regular work on film and television playing working-class, regular-Joe characters.
This so-called neutral scenario ([13], [16], more appositely a neutral-niche scenario) has no steady state outcomes in the analyses and simulations described here, because setting all αij = 0 (i≠j) allows indefinite expansion of S and hence also of N. A slightly less extreme neutral-niche community is modelled by setting all interspecific impacts to a common low value.
"Facebook and Twitter are booming, LinkedIn is holding steady and even Myspace seems to have settled into a niche.
From selling bouquets of rotting flowers to providing curious genealogy searchers with a custom DNA test, whatever idea you've come up with, the smaller the niche, the more rabid the fanbase; the more rabid the fanbase, the more steady sales; the more steady sales, the less time you'll have to read articles like this.
Under steady state conditions, HSC reside in a dormant state within their stem cell niche.
Hematopoietic stem/progenitor cells (HSPCs) escape their BM niche in response to chemotactic gradients and can be detected in the PB under steady state conditions [ 7].
