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Apigenin induced a rapid and steady activation of p38 that coincides with the 'early' phosphorylation of Hsp27 and a 'late' phosphorylation of Hsp27 concurrent to the activation of ERK and PKC δ.
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The population-averaged, steady state activation of lux by the two HSL signals is readily described by a quantitative, competitive inhibition model.
We multiplied the fully activated current amplitude of Figure 5(b) by the steady-state activation of Figure 5(a) to arrive at the steady-state current amplitude of Figure 5(c).
In combination, the steady-state activation of Figure 5(a) and the fully activated current amplitude of Figure 5(b) determine the amplitude of I f that can be activated at −60 mV.
PURPOSE: About 65%to70%0% of melanomas harbor a mutation in v-raf murine sarcoma viral oncogene homolog B1 (BRAF) that causes the steady-state activation of extracellular signal-regulated kinase (ERK).
Finally, in mdx cardiac myocytes, absence of dystrophin shifted the steady-state activation of DHPR towards more positive potentials [44] or prolonged channel inactivation [45].
As steady-state activation of L-type Ca2+ channels at a given membrane potential, d∞, is a determinant of imax amplitudes [51], a possible shift in activation curves might explain amplitude differences between strains.
In addition, the effects of martentoxin on steady-state activation of α+β1 subtype was studied by the same experimental voltage protocol and the same data analysis as gBK channels (see "Data analysis").
In the presence of cytoplasmic Ca2+, martentoxin could enhance the activities of both gBK and BK channel (α+β1) subtypes in dose-dependent manner with EC50 of 46.7 nM and 495 nM respectively, while not shift the steady-state activation of these channels.
The steady-state activation of ICaT was adopted from previous modeling studies (36, 89).
Correspondingly, neither 10 μM (R)- 2 nor 10 μM (S)- 3 affected the steady-state activation of VGSCs.
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