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Moreover, it may establish whether the cellular environment confers the pro-inflammatory phenotype depending on the disease stage and status of remission.
Interacting these two variables we found that the lowest risk of death was associated with the earliest and most persistent status of remission.
15 Despite the lack of power of this study, mainly due to the low number of events in the remission group, these data support a tendency toward a better outcome in patients with a persistent status of remission, as our data show.
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In conclusion, our study shows that biologics increase the chance to achieve clinical remission and a status of functional remission or at least physical independence.
We found that biologics, in particular anti-TNF agents, increase the chance to achieve clinical remission and a status of functional remission or at least physical independence in RA patients treated in routine care.
Therefore, the question whether early achievement of a status of clinical remission might be associated with a significant decrease is still to be answered.
The status of complete remission was based on the assessment made by the treating oncologist based on established criteria (Durie et al, 2006) with corroboration by pathology results.
14 The second group comprised patients with longer mean symptom duration, higher disease activity, higher disability, but, probably due to a more intensive treatment strategy, a higher proportion of patients from the second group achieved a status of clinical remission.
The encouraging data we present suggest that the vast majority of patients with RA monitored in outpatient clinics in the new millennium can expect to achieve a status of clinical remission or low disease activity.
RYGB surgery improved liver insulin sensitivity –as measured by HOMA-IR– regardless of diabetes status, while remission of T2DM was associated with normalisation of fasting plasma insulin concentrations and HOMA-IR values.
Logistic regression techniques were also be used to calculate likelihood of remission status over time (with past remission status used to predict remission status at a specific time point).
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