Sentence examples for status of atm from inspiring English sources

Whether the newly developed ATM-p53 RT-MLPA assay also predicts for clinical outcome in addition to the molecular status of ATM and/or TP53 needs to be further evaluated in large clinical prospective studies.

Quantification of these markers indicated that their prevalence was not affected by the status of Atm (Fig. 4B).

Bmi-1 phosphorylation was unimpaired regardless of the status of ATM, although total levels of Bmi-1 decreased in Atm-/ NSCs (Figure 6A).

However, unexpectedly, the status of Atm did not affect the latency of 3MC-fibrosarcomas neither in a p53-wt context nor in a p53-super context (Fig. 4A; statistical analyses indicated in the legend).

Quantification of the number of lesions indicated that the status of Atm had no significant impact on tumor incidence (Atm-wt: 8.1 lesions/mouse; Atm-null: 7.2 lesions/mouse; n = 15 per genotype).

Collectively, we conclude from the above data that senescence at the pre-malignant stages of K-RasV12-driven lung tumorigenesis is not associated to a detectable DNA damage response and it is independent of the status of Atm.

Mutational status of TP53, ATM, NOTCH1, SF3B1, IgVH status, the presence of +12, del(13q), the Rai Stage, the positive expression of CD38 and ZAP70, β2-microglobulin and LDH serum levels, and a B-cell count⩾11 × 10/l were evaluated in a univariate Cox regression, both for TTFT and OS (Supplementary Tables 2A and B).

To monitor ATM activation, we examined the phosphorylation status of three well-characterized ATM targets: ATM autophosphorylation at Ser1981, CHK2 at Thr68, and transcription/chromatin regulator KAP1 at Ser824 (Shiloh and Ziv 2013).

In the present study, 483 Norwegian breast cancer patients were screened for carrier status of six different ATM mutations found in Norwegian AT patients.

Furthermore, it has also been shown that the combined status of p53 and ATM are also important in predicting drug sensitivity.

Analysis of data was carried out using SPSS software version 17.0 to evaluate association between methylation status of APC and ATM genes and clinical parameters by χ2 and t tests.