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The FGF13, FGFR3, IRS4 and SOX3 are genes reported to be involved in rare syndromes characterized by short stature (Table 1).

When the phylogenetic signal is controlled for, FST depends on FIS, tm, growth form and species stature (table 1).

Similarly, analyses of WCHtR and tibia length did not differ greatly from analyses using stature (Table 3, Fig. 1b), again supporting the validity of the results based on height.

The Circos image represents all 26 significant genomic regions, names of important candidate genes for bovine stature (Table 2), and the locations of all the orthologous genes from human GWAS (Table S4).

The weak predictive power for our models of BMI and the disparity between the two countries, as well as with previous studies which have considered psychological factors and BMI, could reflect limitations of BMI as an indicator of obesity [ 13], particularly in populations of short stature (Table  1) such as the Portuguese.

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The minimum, maximum and mean values for all measurements and living stature were tabulated (Table 1).

The only other TS feature shown by SM1 was short stature (Supplementary data, Table SI).

It is therefore likely that the haploinsufficiency of possible ovarian determinants located in the monosomic regions contributed to the POF, as well as the haploinsufficiency of the SHOX gene (MIM *312865), located at Xp22.3, which is responsible for the patient's short stature (Supplementary data, Table SI).

The regression equations for stature estimation were presented (Table 2).

As for FST, FST' depends on FIS, tm, stature and growth form (table 1).

If physical examination reveals disproportionate short stature, a skeletal survey (Table 2) is recommended to look for evidence of a skeletal dysplasia.

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