Exact(1)
The tyrosine phosphorylation and activation of STATs results in the upregulation of STAT target genes, including three families of inhibitory proteins, the protein inhibitors of activated STATs (PIAS), the SH2-containing phosphatase (SHP), and SOCSs [38], [39].
Similar(59)
Formation of such receptor complexes (receptosomes) increases the docking sites for STATs, resulting in more efficient dimerization of these STATs and enhanced responses to IFNγ and IL-6.
Different combinations of these Stats result in different transcription factor complexes and binding to two different classes of response elements (Kalvakolanu 2003).
In total, 419 i-STAT results were excluded from the analysis because of instrument malfunction.
The major reason for missing results was the unavailability of i-STAT results due to a malfunctioning analyzer or an interrupted supply of test cards.
All A-stat results were reproduced with relative standard deviation less than 10% with the exception of acetate production per biomass (YOAc-) (Table 1 and Figure S1 in Additional file 1).
The latter activates the Akt family of kinases and signal transducer and activator of transcription (STAT), resulting in downstream events that regulate cellular proliferation, survival, and migration (Bonaccorsi et al, 2004, 2007; Migliaccio et al, 2006; Léotoing et al, 2007).
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