A previous study found that when the sample size reached at least 500, the statistics analyzed from the sample are likely the same with the parameters in that particular population [ 39].
Also let X (1),X (2),……,X (n) denote the order statistics from this sample.
Our meta-model partly addresses the first limitation by exploiting the familial structure captured by dense whole-genome predictors, and increases the statistical power through the GWAMA risk score, which is based on summary statistics from the largest sample size currently available.
By comparing the final sequencing enrichment statistics from the same sample prepared with either 3,000 ng or 500 ng starting material, the reduced input does not have any significant effect on target enrichment or library complexity (Table 1).
First, the observed summary statistics S∗, and the summary statistics of the prior samples S = (S 1, …, S n ), are standardized using the means and standard deviations of the statistics from the prior sample (i.e., the prior mean is subtracted from each statistic, and the difference is divided by the prior standard deviation).
RMA expression statistics from the 12 samples were modeled in a 2 × 3 block design, sex by day 0, 3, and 6 post infection, with mouse modeled as random effect.
Samples from the posterior distribution of R 0 were calculated from those of β and α using the following formula [ 5]: (7) R 0 = β α where β is the transition rate from S to I, and α is the transition rate from I to R. Results, in terms of summary statistics from the posterior samples, are shown in Table 1.
Data from patients and matched control participants who could not be identified in the Income Statistics database were excluded from the sample.
The bias was expressed as a ratio of statistics from test sample size to the reference sample.
To prevent duplicative data reporting, only effect sizes and p values determined using logistic regression are presented to indicate the significance of these comparisons; previously published descriptive statistics from the state-funded quitline sample are not presented.
