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It can be argued that in cases when the statistically imposed constraints match the anticipated physics of the system, the unmixing will directly provide the insight to the latter.
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HMM method analyses and fits the data statistically without imposing a preconceived model (described in Materials and methods).
For example, the association between the HLA-C allele and viral load exceeded the threshold for statistical significance imposed by a GWAS, but the association of this allele for disease progression was not statistically significant [27].
According to ANOVA results, the addition of MWCNTs at 1.5 wt% was seen to impose statistically significant physical effects on electrical resistivity of the nano-composite.
It is also limited by restrictions that we imposed to focus on statistically significant patient cohorts and on non-hypermutated genomes (see Methods section for details).
These model parameters were not simply imposed on the analysis, but were tested statistically with a likelihood score to assess whether the additional parameters are justifiable on statistical grounds.
It creates "statistically wasted" votes.
This level of fidelity is not statistically different from that found in the experiments (Table I) using imposed synchronies of 12% missegregation (P=0.08, Fisher's exact test).
According to the Table 4, the only factor imposing a statistically significant physical impact on electrical resistivity of the samples was feed, because the associated p value (significance level) with this factor only was less than 0.05.
Additionally, even with limitations imposed by the short length of sequencing reads, we were able to observe statistically significant linkage among polymorphic sites in evolved lineages.
The 5% minimum difference was chosen to enforce non-negligible magnitude of effect (on top of the statistically significant differences used to define the clusters) and acted as a strong requirement when imposed simultaneously upon all the 12 cancer types.
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CEO of Professional Science Editing for Scientists @ prosciediting.com