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However, there is little statistical rationale for such a procedure.
This study proposes an alternative sampling regimen (number of sampling points, number of samples from each sampling point) and setting of the acceptance criteria for blend uniformity based on a statistical rationale.
The unbalanced sample size (1∶2∶2∶2) was by this time established and could not be revised retrospectively although the statistical rationale for it was not present with the revised design.
Clinical, as well as statistical, rationale is required for combining treatments.
Statistical rationale largely centre upon increasing sample size (e.g., increasing statistical power and detection of low frequency events).
Each method had a different statistical rationale and could be expected to identify different features of the compendium.
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By the nineteen-eighties, the kind of evidence that was routinely admitted into court without any statistical grounding or rationale had earned a name: "junk science".
2) Claims about effects of mutations are made without appropriate statistical analysis and rationale.
In December 2003, a protocol for the meta-analysis, describing the study rationale, statistical methods, and guidelines for publication, was distributed to the principal investigators of the five trials.
Table 1 lists a range of theoretical, statistical and practical rationale for pooling individual participant data, which arose from our own observations, as well as from existing discussion in the literature (e.g., [ 1, 18, 20]).
The molecular assays used in the study are unreliable at high levels of contamination of the tumour samples with normal tissue, therefore samples with estimated contamination above 65% were excluded from statistical analyses (the rationale for this cutoff is explained in the Supplemental Results and in Supplemental Figures S7, S8, and S9).
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