These 1091 parameters define the BACH statistical potential.
We here introduce a statistical potential that we call BACH Bayesian Analysis Conformation Huntt).
Rykunov, D. & Fiser, A. New statistical potential for quality assessment of protein models and a survey of energy functions.
We here present a novel statistical potential constructed by Bayesian analysis measuring a few structural observables on a set of 500 experimental protein structures.
The solvation statistical potential ESOLV is based on classifying all residues in two different environmental classes, either buried (b) or solvent exposed (s).
The single residue statistical potential ESOL requires two separate parameter sets, for overall 40 parameters: ei = b or s is the environmental class of residue at position i.
Experiments confirm that our position-specific statistical potential outperforms currently the popular ones in several decoy discrimination tests.
The pairwise statistical potential EPAIR requires five distinct symmetric matrices, where a and b vary among the 20 aminoacid types, for overall 1050 parameters: ai is the aminoacid type of residue at position i, and xij is the structural class to which residue pair i - j is assigned.
We also constructed a novel structure-based statistical potential, called STATIUM, which is remarkably good at predicting Bcl-2 affinity and specificity, especially considering it is not trained on experimental data.
Different from other statistical potential, this potential does not use distance to classify the residue-base pairs directly.
The GOLD software has four scoring functions namely ChemPLP, GoldScore, ChemScore, and ASP (the Astex Statistical Potential) which take into account the terms of hydrogen bonding, van der Waal and intramolecular energies.
