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The statistical plan for the trial uses a design that evaluates the HR of febuxostat to allopurinol based on the primary CV composite end point when there are a maximum of 624 CV events.
The statistical plan for the trial uses a design that evaluates the hazard ratio (HR) of alogliptin to placebo first based on the primary CV composite end point after accrual of 80 to 150 primary CV events and again when there are 550 to 650 primary CV events.
RL, EvT, PB developed the statistical plan for this protocol.
AJ assisted in the development of the statistical plan for this protocol.
Furthermore, our statistical plan for model selection, which included the use of MAEs, RMSEs and tests for heteroskedasticity was in keeping with recommended diagnostic approaches [ 22].
Efficacy subgroup analysis based on any prior treatment, prior laser treatment, and no prior laser treatment was included in the statistical plan for the study.
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The Scheffe net statistical planning for mixtures was used to relate the component mass fractions to the relative breakdown of petroleum emulsions.
It is proposed that statistical planning for the use of enzymes derived from nematophagous fungi is a viable way to elucidate some questions about their mechanism of action.
Hence, the statistical plan provided for an analysis of outcomes based on prior chemotherapy failure, and using this pre-specified comparison, subjects showed a clinically meaningful and statistically significant difference in overall survival favouring the combination of Onconase + Doxorubicin (hazard ratio 1.45; p = 0.033).
UA is responsible for statistical planning of the trial.
The information on the distribution and variance in the data provides valuable information for statistical planning of health economic studies.
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