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To be valid, a laboratory's reference interval should account for differences in chemical methodology and reproducibility of that method, but statistical methodological concerns are also of importance.
Finally, some future perspectives and topics for further statistical methodological research will be presented in order to spur statisticians to meet the challenge of efficiently designing and analysing the clinical trials of tomorrow.
To identify sources of heterogeneity (statistical, methodological, and clinical) in studies evaluating non-steroidal anti-inflammatory drugs (NSAIDs) vs acetaminophen in patients with knee and hip osteoarthritis (OA) to elucidate variations in outcomes.
In this paper, using a statistical methodological approach based on DoE technique and multivariate analysis of flame treatment process parameters, a mathematical model of SFE and wettability is obtained.
Sixty-four (64.6%) of the resources (statistical, methodological, consensus guideline resources) were assessed for validation.
We will explore the potential sources of statistical, methodological and clinical heterogeneity.
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Furthermore, it is focused on the study design and to the statistical-methodological aspects related to their identification and combination in a composite score, with special reference to the colorectal cancer screening setting.
This has allowed us to identify good practice, useful statistical methods, methodological challenges (Table 2), and some limitations in current reporting and methodology to be addressed (Table 3).
Researchers reported considerable evidence that many statistical and methodological errors were common in published papers and that authors often failed to discuss the limitations of their findings.
Some studies that found an association between job stress and hypertension had major statistical or methodological weaknesses that called their results into question, the researchers said.
This helped them correct for statistical and methodological problems with the previous studies, allowing them to reach more precise and reliable conclusions about whether acupuncture actually works.
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