Exact(11)
The residual error between the predicted score of a model and the corresponding MOS value in the IEEE-SA database can be used to test the statistical efficacy of the model against other models.
In 2014, a meta-analysis of four randomized phase-III trials (EORTC 22921, I-CNR-RT, PROCTOR-SCRIPT, CHRONICLE) failed to demonstrate any statistical efficacy of fluorouracil (5FU -based ACT.
In addition, including more studies increased the statistical efficacy.
An adaptive two-stage trial design was utilized, which was stopped after the first stage due to statistical efficacy.
Such patients could remain in the study but were considered non-responders for statistical efficacy analyses after initiation of rescue therapy.
The result then, is a requirement to enlist very large numbers of patients to show statistical efficacy of the new drug; this is incredibly expensive and time-consuming.
Similar(49)
Third, with the exception of the primary end point (the global investigator score), statistical comparisons of efficacy data had to rely on non-parametric statistics because of lack of normal distribution of the data.
Drugs with unknown clinical patient benefit or statistical significance of efficacy (data unavailable or insufficient).
In contrast, preclinical antiviral evaluations require groups of animals sufficiently large to demonstrate statistical proof of efficacy in vivo.
Therefore statistical proof of efficacy is challenging.
Statistical analysis for efficacy was performed on the pharmacodynamic population.
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