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This avoids both an artificial length scale and the statistical compromises necessary when operating on individual markers, such as the impact on multiple-hypothesis testing when measurements are partially dependent (Methods S1).
Overlap between known positive and known negative examples makes the process of choosing a cutoff difficult, often requiring some statistical compromises.
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Poorly posed hypotheses, badly planned study protocols, inaccurate data collection and wrong statistical analyses compromise the quality of the final manuscript much more than do writing errors, often irreversibly.
This could create dependency among the data, which potentially compromises statistical tests [ 46].
Moreover, complex diseases are often evaluated using a single phenotype that compromises statistical analysis by introducing errors such as misclassifications, and/or lack of accountability for disease severity [ 109].
First, the sample size was modest, and may have compromised statistical power, thereby increasing possibility of Type II error (failure to detect actual differences).
Many studies fail to recruit enough patients which compromise statistical power.
The small sample size may have compromised statistical power for the analyses.
Limitations: Some limitations should be addressed in our study, namely a low sample population could compromise statistical power.
This can affect precise quantification of perfusion, affect the perfusion status of individuals, and compromise statistical validity.
Being a rare diagnosis, the identification of prognostic factors and their statistical evaluation is compromised by the small number of patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com