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Data management and analyses were conducted according to a pre-specified (common for all participating countries) statistical analytical plan that provided descriptive summary statistics only [mean and standard deviation (SD) for continuous data; number and percentages for categorical data].
PROC MEANS procedure of Statistical Analytical Systems (SAS) 9.3 (SAS 2012) was used to estimate the descriptive statistics, viz.
Various statistical analytical tools have been used in this study for analyzing the data.
Data analysis was done using multi-variate statistical analytical software SIMCA -P + (V12, Umetrics AB, Umea, Sweden).
CyTOF data was analyzed by several statistical, analytical and visualization tools including hierarchical clustering, orthogonal scaling, SPADE, viSNE, and SLIDE.
General linear model procedure of statistical analytical system was used to obtain the variance components for the estimation of heritability.
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