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Statistical analyses were corrected for the oversampling of malformation cases.
All statistical analyses were corrected for multiple comparisons at the peak voxel level using the family-wise error (FWE).
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As an exploratory investigation, group sizes were small and statistical analyses were not corrected for multiple comparisons.
Analyses were performed in STATA [ 19] and as our sample included individuals from the same families, statistical analyses were conservatively corrected for the non-independence of observations using the 'robust' cluster command as is standard in analyses of this type (see [ 20, 21] for more information).
However, additional statistical analyses were undertaken correcting for these imbalances and they were found to have no qualitative effect on the efficacy conclusions.
All statistical analyses were performed on this corrected dataset and homozygosity persisted after corrections.
For this reason, all statistical analyses were conducted on scores corrected for baseline performance by subtracting false alarms (incorrect decisions on non-studied targets) from hits (correct decisions on studied targets).
All statistical analyses were weighted for national representation and corrected for complex survey design using Stata V.11.1 (Stata Corp).
Statistical analyses were performed by logrank Mantel Cox test corrected for multiple comparisons, with p ≤ 0.0083 considered significant.
All statistical analyses were performed using R. False Discovery Rate (p<0.05) was applied to correct for multiple comparisons.
All data sets were baseline-corrected and area-normalized before statistical analyses were applied.
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