Exact(1)
Unless stated otherwise, we used a false discovery rate (FDR; calculated per MAFDR, MATLAB) statistic set at P<0.05 (Benjamini and Hochberg, 1995; Storey, 2002); this same approach is well-accepted to manage familywise error rates in gene expression experiments involving >10,000 potential comparisons.
Similar(59)
We tested the regression coefficients in the model using the likelihood ratio test and the Wald statistic setting significance at α = 0.05.
24 The presence of between-studies heterogeneity was assessed by the Cochran Q statistic (significance set at p<0.10) and quantified by the I² statistic.
The critical level for the z statistic was set at 1.96.
If the significance cutoff level for detection by the likelihood-ratio test statistic is set at the P = 0.001 level, for the conditions shown, a minor allele must have a frequency in excess of 10/ N to be detectable with near certainty, and even for a power to detect 10% of the time, the minor-allele frequency must exceed.
The genome-wide significance threshold of the z-statistic was set at ± 4.2 for the two panels of AIMs and ± 4.7 for the panel based on random markers.
For the Q statistic, statistical significance was set at P<0.1.
The level of statistic significance was set at P < 0.05.
P-values were obtained from the moderated t-statistic and statistical significance was set at p<0.05.
Heterogeneity was also assessed by means of the I statistic, with significance being set at I > 50%.
Inter-study heterogeneity was tested by the Q statistic with the significance level set at P < 0·10 and quantified by the I statistic, where I ≥ 50 % is the evidence of substantial heterogeneity.
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