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Many statistical tests assume a normal distribution, so we will describe a statistic derived from that distribution.
Statistical significance for univariate differences in prevalence was determined using the t statistic derived from the general linear contrast procedure.
The size of company nodes is determined by their "indegree," a statistic derived from directed graphs that counts the number of inbound connections to that node.
Various methods based on topology have been used [23], [24] but in its current implementation, Velvet only relies on contig coverage values, using a statistic derived from the A-statistic [25].
The summary statistic derived from each study was the prevalence of specific DS use.
cSlope of a marker is a summary statistic derived from measurements of a patient.
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**Difference in Difference t-statistic derived from a generalized linear mixed model with a logit link and binary distribution adjusting for baseline demographics, Deyo-Charlson comorbidity index, and pre- and post-index non-opioid pain medication utilization.
The t-statistic derived from datasets with 20 replicates was used as a surrogate "gold standard" since 8 or more replicates can be considered sufficient to give power to the t-statistic [ 17].
*Difference in Difference t-statistic derived from a generalized linear mixed model with an identity link and a Gaussian distribution adjusting for baseline demographics, Deyo-Charlson comorbidity index, and pre- and post-index non-opioid pain medication utilization.
Model discrimination was assessed by the C-statistic derived from calculating the area under the receiving operating characteristic curve (interpretation of c-index: excellent ≥0.90, adequate 0.70 to 0.89, poor < 0.70) and the generalized max-rescaled R-squared statistic [ 18, 22].
We also calculated the D statistic 25 and R statistic 26 (derived from the D statistic), which are measures of discrimination and explained variation respectively and are tailored towards censored survival data.
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