Shown are correlations between receptor activator of nuclear factor-κB ligand (RANKL) mRNA levels (or RANKL mRNA/osteoprotegerin [OPG] mRNA) in bone and serum RANKL levels, and various structural parameters, static indices of bone turnover and biochemical bone turnover markers.
We investigated relationships of bone RANKL mRNA levels and serum RANKL levels with trabecular bone structural parameters, static indices of bone turnover and biochemical markers of bone turnover.
No significant relationships were observed between OPG mRNA, or serum OPG levels, and trabecular bone structural parameters, static indices of bone turnover, or circulating or urinary bone turnover markers.
The structural parameters of trabecular bone and the static indices of bone turnover, determined using histomorphometric analysis, and biochemical measures of bone turnover were similar in the male and female groups (Table 1).
The aim of this study was to compare the cancellous bone structure, and static indices of bone turnover, in female patients, who had sustained fragility fracture at the femoral neck, with age-matched females without fragility fracture.
The static indices of bone turnover, eroded surface (ES/BS) and osteoid surface (OS/BS), were positively correlated with age in the > 65-year-old control group (p < 0.055 and p < 0.03, respectively).
In terms of the static indices of bone turnover, there were significant positive relationships between the RANKL/OPG mRNA ratio and ES/BS and OS/BS, which is consistent with our previous findings [ 7].
The localization of coronin to the dense actin layer surrounding the neck of the particle suggests that this layer is not static but is subject to continuous turnover.
Similarly, photoactivated FtsZ has shown monomers to be immobile in vivo, also in line with turnover by treadmilling, with static monomers in the filament.
Although turnover in 2012 remained fairly static at £2.7bn, the Rocester-based firm announced a profit of £365m, up £10m on the previous year.
