Exact(9)
Static inflation lung compliance measurements were performed as previously described [18, 21].
The increase in alveolar epithelial permeability to small hydrophilic solutes has been studied by Egan during static inflation of fluid-filled in situ sheep lobes [25, 26].
In the present study, we observed the effects of lung static inflation, different perfusates, and ventilatory gas with nitrogen or oxygen on the I/R-induced pulmonary damage.
In this regard, our investigation is inspired by the recent works of Bucchi and Hearn (2013) [28], [29], who carried out a constitutive sensitivity analysis of similar problem with hyperelastic cylindrical membranes subjected to static inflation.
Static inflation lung compliance was measured immediately prior to a recruitment manoeuvre, ensuring a standardized lung volume history.
The increase in alveolar epithelial permeability to small hydrophilic solutes has been studied by Egan during static inflation of fluid-filled in situ sheep lobes [ 25, 26].
Similar(51)
Prior to each condition change, two static inflations to 40 cmH20 were performed via the syringe technique and held for 20 seconds each to ensure a standard volume history between conditions.
Unfortunately, CT technology does not permit the acquisition of CT sections of the whole lung at a fixed inspiratory pressure during a quasi-static inflation maneuver.
Whereas a defined initial delivered volume would potentially achieve more consistent volume inflation of the non-aerated lung, the inflation pressure required to achieve the predetermined volume would be variable and could result in exposure of the immature lung to potentially injurious high static inflating pressures, and possibly pneumothoraces.
This suggests that large, but mainly static, lung inflation does not permanently alter the integrity and permeability of the blood-gas barrier.
Quasi-static and dynamic inflation of a dielectric elastomer membrane.
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