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In one such case involving the endogenous immunoglobulin heavy chain (IgH) locus, removal of the enhancer from the IgH locus of a B cell line creates conditions in which the heavy chain gene can exist in different states of expression, ranging from highly expressed to silent [6] [8].
In all cases, the transition between the silenced and active states of expression is accompanied by histone acetylation and other post-translational histone modifications [1].
Some evidence suggests that the occurrence of multiple states of expression is in some way related to the action of transcriptional enhancers (reviewed in [5]).
Thus, genes that have been manipulated to lack an enhancer can sometimes exist in at least two states of expression for many weeks.
Such a result suggests that the active and inactive states of expression are each autocatalytic: that expression above a specific threshold increases the likelihood that the locus will remain active, while expression below that threshold decreases the likelihood of activity.
These considerations raise the question whether other methods of weakening expression, such as reducing the strength of the promoter or reducing the concentration of specific transcription factors would likewise allow different states of expression that can be transmitted to progeny cells.
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Someone who as an American, having freedom to do so, searching for a pure state of expression, whether religious philosophy or some kind of philosophy, going from that search to being where he wound up".
Our lives are spent in a constant state of expression these days with texting, tweeting and more.
Yet, the thick paint that adorns his face has trapped him in a state of expression somewhere between fear and mourning.
The state of expression of the genes in the entire network (herein, configurations of the GRN, which correspond to "dynamic state of the network" used by some authors), is then represented by a vector with the set of Boolean variables {x1,..,xN}xN}, where xn is the state of expression of the nth gene and N is the total number of genes in the network.
Now, we must consider import of zinc to activate proteins that maintain a steady state of expression as a potential regulatory step.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com