The input-state incidence matrix of a control Boolean network is proposed.
The application of input-state incidence matrix to the controllability of μth order Boolean control networks is studied.
However, this increase in UP state incidence was not statistically significant (t5 = 1.5, P = 0.18; one-sample t-test; h0 = normalized UP state incidence after SCH22390 application was 1).
In the previous experiment, application of 200 n m raclopride appeared to cause a small but significant increase in UP state incidence (Fig. 3E).
We observed no significant relationship between the baseline UP state incidence and the change in UP state incidence after bath application of dopamine alone (r = −0.50, P = 0.39; n = 5; Pearson's correlation test), dopamine and raclopride (r = 0.62, P = 0.18; n = 6) or dopamine and SCH23390 (r = 0.06, P = 0.92, n = 6; Pearson's correlation test).
Expected number of cases per county (e) were calculated by using a validated equation e = (r × n) (c), where r is the state incidence rate, n is the state population, and c is the county population (5, 8).
We found that blockade of D1-like receptors with the antagonist SCH23390 prevented the dopamine-induced suppression of UP states, although there still appeared to be a small, but non-significant reduction in UP state incidence (Fig. 3A).
We used the Moran's I test for spatial autocorrelation to assess geographic clustering of state incidence rates of Lyme disease and of death rates for the 4 neurologic disorders by using ArcGIS 10.1 (ESRI, Redlands, CA, USA).
First, the model outcome is obtained when an optimal mix of different prevention strategies is applied in the population and a steady-state incidence of CC is achieved across the population.
Bath application of 10 μ m dopamine reduced the incidence of UP states (Fig. 2A and B); after 10 min, spontaneous UP states were almost entirely suppressed (UP state incidence, baseline vs. 10 μ m dopamine: 3.3 ± 0.67/min vs. 0.04 ± 0.03/min; t4 = 4.8, P = 0.0089; n = 5; paired t-test; Fig. 2C).
