The C-terminal "BAG domain" of BAG-1 mediates the interaction with the Hsc70 and Hsp70 heat shock proteins [ 3], molecular chaperones that bind proteins in non-native states assisting them to reach a functional active conformation [ 4].
The core of the BAG domain comprises two anti-parallel alpha-helices that mediate interaction with the HSC70 and HSP70 heat shock proteins (Briknarova et al, 2001; Sondermann et al, 2001), molecular chaperones that bind proteins in non-native states assisting them to reach functional confirmations.
Any treaty advancing the Japanese privileges to the present status of European aliens would be fought by Senators from the Western states, assisted by Senators from the South, who have their own race problems, making them sympathetic with the Western Senators.
European Union (EU) regulations and civil-law cases within EU member states, assisted by broadened EU and member-state laws regulating tort cases, are similarly inclined, even to the point of referencing customary international law to reinforce legislative intent and allow for universal civil jurisdiction on a "necessity basis".
He opposed the Mexican-American War, but acceded to federal demands that the states assist in raising troops for the war, earning the wrath of activist Wendell Phillips.
First, they believed in the beneficent power of the state, assisted by science and technology.
On Tuesday, Gov. George E. Pataki proposed that the state assist the victims' families by either paying for public universities in the state or giving comparable sums for expenses at private campuses in the state.
This attempt to comprehensively "regenerate" a part of London through a close partnership between corporate wealth and the "local state" assisted by political friends in higher places focuses key questions about how London should meet the challenge of a fast-growing population - driven mostly by high birth rate - in urgent need of more homes, jobs and quick, reliable ways of getting around.
How could the State assist private residential colleges to help in these efforts?
HSPs in the normal cell state assist in the folding of native polypeptides, and their induction under stress conditions prevents production of cytotoxins and stabilises denatured proteins (e.g., [32], [58], [59]).
Molecular chaperones are a diverse family of proteins expressed by both prokaryotic and eukaryotic organisms that serve to maintain correct protein folding in a 3-dimensional functional state, assist in multiprotein complex assembly and protect proteins from irreversible aggregation at synthesis and during conditions of cellular stress [ 267].
