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I don't think the statement is ambiguous at all.
As written, the statement is ambiguous and confusing in the sense that what you really mean is that certain substitutions that occurred during the reverse evolution process are incompatible with some of the residues present in the ancestral/original protein.
Yet, this statement is ambiguous since it is uncertain what kind of pairings make up a stem only Watson-Crick pairings or also interactions such as G-U and G-G.
Similar(55)
Najib Mikati, the current prime minister, issued a policy statement on Thursday for his newly appointed cabinet, in which he said he would honor those pledges, though the wording of the statement was ambiguous.
Lawyers for the defense conceded that the statement was ambiguous (the State of Maine specifically instructs drafters of legal statutes not to use the serial comma) but argued that it had "a latent clarity".
The witnesses' statements were ambiguous, and there was not independent corroborative proof (like an audio tape) that would have allowed us to sustain our burden of proof.
In the above thesis statement, the word "should" is ambiguous.
"I would wish that the administration move to explain what is ambiguous in the statement to avoid interpretations that may contradict or undermine it," Mr. Mubarak told reporters in Cairo.
"The vast majority of the members of the council believe that it would not be productive for there to be a statement that was ambiguous in some fashion," Ms. Rice said, noting that the American position was that "we think that it is very important for the council to be able to speak with clarity and unity to condemn these attacks as unprovoked aggression by D.P.R.K. against the Republic of Korea.
We did not mean for this statement to be ambiguous.
The statement 'what is best for a child is different in different cultures' is ambiguous.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com