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Data were collected on mean pharmaceutical usage per sequela occurrence until resolution (brand of pharmaceutical = mean singular dosage * mean daily frequency of stated dosage * duration of use until resolution).
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Doses exceeding this high dose regime were defined as elevated doses.> -wrap-foot> Legend: if not stated otherwise: dosage approved by the national authority.
When elaborating this reasoning we have to be careful not to confuse unidirectional compensation with dosage effect: if a gene phenocopies a stimulus, we might expect to see that its deletion amplifies the effect of this stimulus, showing higher sensitivity to its application (loosely stated, higher dosage of the stimulus).
Edger et al. [ 76] stated that dosage-sensitive genes, including transcription factors, were preferentially retained following WGDs, which is compatible with the present study.
The respondents in quake areas were asked to state a dosage of medication for an earthquake victim.
Alternatively a GMP certificate stating the dosage forms manufactured may be submitted.
For example, only 36%and53%3% of ASHAs stated the correct dosage for children 2 5 months and 6 59 months of age, respectively.
Do not take more than the recommended dosage stated on the pain medicine bottle, unless otherwise advised by a physician.
This hypothesis states that dosage-sensitive genes are preferentially retained after whole genome duplications rather than in cumulative small-scale gene duplications, especially if these genes cooperate in the same complex regulatory or interaction pathway and network [ 109- 111].
Unless otherwise stated, standard drug dosages were used in the studies: (1) TDF 300 mg once daily; (2) AZT 300 mg twice daily; (3) d4T 30 or 40 mg twice daily; (4) 3TC 150 mg twice daily or 300 mg once daily; (5) FTC 200 mg once daily; (6) NVP 200 mg once daily for a 2-week lead-in period and then as 200 mg twice daily; and (7) EFV 600 mg once daily.
The 1993 Workshop Report on extended-release dosage forms stated that "in order to utilize an IVIVC, the adequacy of the in vitro method to act as a surrogate for in vivo testing must be demonstrated" (2).
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