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All 291 samples contained the stated active pharmaceutical ingredient (API) of which 69% were considered good quality by chemical analysis.
Capsules of Miltefos™ were classified as falsified (absence of stated active pharmaceutical ingredient) by three methods NMR and mass spectrometry analysis and bioassay.
Definitive drug quality was measured using high-performance liquid chromatography photodiode array detection (HPLC-PDA) for content of the stated active pharmaceutical ingredients (APIs) and bioavailability was determined with in vitro dissolution testing.
Evidence of poor-quality antimalarial tablets originated from southeast Asia where "counterfeit or fake" 16 antimalarials were found with very sophisticated packaging that mimicked an existing brand but did not contain the stated active pharmaceutical ingredient (API).
No products were detected that did not contain any amount of the stated active ingredient.
The other sample which did not give the pink or blue spots in our assays was from Vietnam which did not contain artesunate the stated active ingredient.
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Critical closing pressure refers to microvascular collapse secondary to steady-state active muscular vascular tension in the presence of vascular elasticity (Nichol et al., 1951).
Some ion channels show such activity, having two functional states, active and inactive, and an additional non-conducting conformational state [4].
When an environmental condition changes, equilibrium between two functional states, active and inactive, immediately shifts to generate a response in the activity of sensory molecules.
Some states active in developing such weapons have committed to not deploy them for the foreseeable future, Mr. Heyns said.
The accelerated growth of new doctors, in-state active doctors, high-risk specialists and doctors who provide direct patient care per capita all exceed pre-reform levels.
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