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Let θ be the probability of switching from state on to state off and of switching from state off to state on.
In our graphic representation, a mechanism of translational regulation is modelled by a hexagon, which is bound (state "on") or not (state "off") to the mRNA.
For case II: Our numerical simulation results show that time delay can also induce the gene switch, however different with case I, the TF-A monomer concentration shifts from the low concentration state to the high concentration state ("off" → on").
Given are: the compared state (PD: patients pre-DBS compared with control volunteers, DBS: PD patients post-DBS on electrical stimulation as compared with pre-DBS state, OFF: PD patients post-DBS following one hour of electrical stimulation cessation.
For case II: Our numerical simulation results show that time delay τ2 can also induce the gene switch, while different from case I, the TF-A monomer concentration shifts from the low concentration state to the high concentration state ("off"→ "on").
In prehospital work, when physicians are not present in the patient encounter, paramedics have in principle the same professional duty to consider the patient's state off ill health.
Similar(6)
Our results indicate that within physiologically and therapeutically relevant ranges for all parameters, a targeted inhibitor can naturally induce a steady state off-target effect via retroactivity.
Using a numeric perturbation method, we identified specific conditions that favored the promotion of steady state off-target effects via retroactivity when a targeted inhibitor was applied to cycle n in a series of simple signaling networks.
An exception was made for the protein YciR, which was assigned a knockout state (off-state) and two different observable activities that are mutually exclusive (PDE activity and YdaM/MlrA-inhibition activity) [ 7].
Thus, two parameters are necessary for this process, the rates of switching between the two states, off and on.
We model the promoter of each gene to switch between two states, OFF and ON, with full-strength transcription only occurring in the ON state.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com