Sentence examples for state of upstream from inspiring English sources

Given that not all rats that receive moderate SCI develop CNP, the current study was designed to further analyze changes in persistent CREB activation and in the activation state of upstream intracellular signaling cascades (e.g., mitogen-activated protein kinases [MAPKs]) in populations of rats that receive SCI and weeks later develop CNP and rats that receive SCI but do not develop CNP.

The correlation coefficient estimates the correlation between two binary variables (inclusion/exclusion states of upstream and downstream exons).

The activation z-score was used to infer the likely activation states of upstream regulators based on a comparison with a model that assigns random regulation directions.

The heat map in Fig.  5b, shows the predicted states of upstream regulators of gene expression that were not categorized as transcription factors or direct repressors of transcription factors, and included G-protein receptors, ligand-mediated and transmembrane receptor proteins, kinases and phosphatase types of molecules.

Expression of the GTP- or GDP-bound mutants of Gtr1-Gtr2 supersedes this unknown Gtr1-Gtr2-independent pathway in the regulation of TORC1 and autophagy by locking TORC1 in an activated or inactivated state irrespective of upstream signals.

IPA upstream regulator analysis allows the identification of the "activation or inhibition state" of specific upstream regulators in a gene set.

To predict the activation state of the upstream regulators ("activated" or "inhibited"), a z-score was computed for each of them.

The state of the upstream-most gene is determined randomly for each individual at simulation initiation, and is then inherited for subsequent generations.

Upstream regulator analysis in IPA allowed the identification and determination of the state of activation of upstream regulators that might be responsible for the observed gene expression changes between different groups.

Hence, we examined whether GALR2 activation affects the phosphorylation state of MEK1/2, immediately upstream of ERK1/2.

Network state changes are governed by logical (Boolean) rules giving the state transition of each node according to the state of its regulators (upstream nodes).