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The presentation of a series of relevant stimuli could be assumed to cause a state of sensitization.
It is thought that this conditioning may be a major factor in relapses that occur in patients months to years after they stop smoking an extremely stressful situation and nicotine receptors that have returned to their normal state of sensitization may be enough for the patient to start smoking again.
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Opioid-induced hyperalgesia (OIH) is most broadly defined as a state of nociceptive sensitization caused by exposure to opioids.
The second shifts the focus from drug addiction to neural sensitization, claiming that triptan overuse triggers adaptations of the trigeminovascular system, thereby facilitating pain transmission and leading to a state of latent sensitization.
Furthermore, there seems to be a state of maintained sensitization of trigeminal nociceptive systems in the brain.
In other words, the current results indicate that the first two PPT trials may have caused a generalized state of increased sensitization of the nociceptors.
Thus, TNF-α induced a state of persistent sensitization of joint nociceptors for mechanical stimuli (a basis for mechanical hyperalgesia), similar to inflammation.
The fact that sensitization can occur in locations distant from the sensitizing stimulus (duodenum) suggests a central site of sensitization.
In this review, we describe the current state of the PTP-sensitization strategy, with emphases on the methodology of identifying PTP-sensitizing mutations and synthesizing the compounds that have been found to target PTPs in an allele-specific manner.
Together, these more likely maintaining, a state of trigeminovascular activation and sensitization.
During development of inflammation in the joint, nociceptive spinal cord neurons develop a state of hyperexcitability (called central sensitization) which increases the gain of the nociceptive processing [ 9].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com