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As HM ChIP-seq data was not normalised to nucleosome density (not assayed), this combination of nucleosome sparsity and TF-modulated chromatin structure presumably explains why HMs provide comparatively little information regarding the regulatory state of housekeeping genes.
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Clonal relationships established via goeBURST are based on the character state of the housekeeping gene allele, and do not take into account the degree of nucleotide sequence heterogeneity.
Following TSA experiments, the mitochondrial ATP6 gene was used for normalization, since interference of this drug with the chromatin state of nuclear housekeeping genes was expected.
As a control, we characterized the chromatin state of the housekeeping gene for condensin subunit SMC2 (also located on chromosome Z).
Wharton moves with assurance among the homely country details of housekeeping and hardscrabble farming.
The GO categories more frequently observed in State 2 match those of housekeeping genes, such as cytoplasm, nucleus, and protein binding.
The National Trust's Manual of Housekeeping states that dry cleaning methods, such as brushing, vacuum cleaning, or even the use of erasers, might be insufficient, and that the deposition of soot can produce "disfiguring, virtually indelible staining" [142].
Multi-locus sequence typing (MLST), a genotyping system based on single-nucleotide polymorphisms (SNPs) of housekeeping genes, has emerged as the state-of-the-art method for resolving bacterial population genetics [4], [5].
This indicates that the current state-of-the-art in promoter prediction is biased toward housekeeping genes that contain CpG islands.
The gene functions or GO categories enriched in State 2 tend to correlate with those of housekeeping genes.
These results suggest TF binding provides more information regarding the transcriptional regulatory state of mammalian biological processes enriched for housekeeping genes.
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