Sentence examples for state of embryonic from inspiring English sources

A pluripotent state of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) is maintained through the combinatorial activity of core transcriptional factors (TFs) such as Oct4, Sox2, and Nanog in conjunction with many other factors including epigenetic regulators.

The negative regulation of caspases has also been shown to be necessary for the pluripotent state of embryonic stem cells [36].

Inhibition of a pro-oxidative cascade that oxidizes highly unsaturated lipids promotes the pluripotent state of embryonic stem cells and inhibits differentiation [50].

Oct-4, as a central mediator of the undifferentiated pluripotent state of embryonic stem cells, may prevent expression of genes activated during differentiation [51].

Intrestingly, we find that inhibition of FGF signaling down regulates expression of Lin28 and FoxD3, two genes which have been implicated in regulating the pluripotential state of embryonic stem (ES) cells [14], [17] [19].

Moreover, transgenic mice over-expressing Suv39h1 display impaired erythroid differentiation both in vivo and when cells are cultured ex vivo where they become immortalized [39], and EHZ2 has an essential role in maintaining the pluripotent/undifferentiated state of embryonic stem cells [40], [41], [42].

Low oxygen tensions (hypoxia) maintain undifferentiated states of embryonic, hematopoietic, mesenchymal, and neural stem cell phenotypes and also influence proliferation and cell-fate commitment.

The tools needed to demonstrate direct interactions are currently not amenable to the rapidly changing network states of embryonic mammals and require a priori knowledge of all the cis- and trans-acting components of an interaction.

Given that low oxygen tensions maintain undifferentiated states of embryonic, hematopoietic, mesenchymal, and neural stem cell phenotypes and modulate proliferation and cell-fate commitment [ 28], it is reasonable to assume that a much lower oxygen tension than that of ambient air in some specific environments of the cochlea may be more suitable for stem or progenitor cell populations to reside.

Complex regulations of the self-renewal and differentiation states of embryonic and adult stem cells and their "stemness" not only heavily rely on transcriptional factor networks, but also on the properties of the chromatin within the cells, the so-called "epigenetic landscape".

This capacity for regeneration -- the ability of cells at a wound site to "dedifferentiate," or return to a state of early embryonic flexibility -- becomes progressively lost in animals that evolve greater adult complexity by von Baer's universal process of "locking in," with increasing specialization of parts.