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Repeated exposures to UVB of human keratinocytes lacking functional p16INK-4a ableable to differentiate induce an alternative state of differentiation rather than stress-induced premature senescence.
We evaluated the state of differentiation of pre-osteoblastic cells.
A particular state of differentiation, then, corresponds to the set of genes that is expressed and the level to which it is expressed.
Moreover, the structure and location of genetic loci display cell type-specific differences and relate directly to the state of differentiation.
Depending on the targeted cell type and its state of differentiation, growth factors can activate or regulate a variety of cellular functions.
Recently, it has become clear that prognosis is determined by the tumour's state of differentiation and by genetic abnormalities that affect cell proliferation and apoptosis.
We propose that HSF2 has an important role at the time of cell fate decision; determining whether the cells remain in a glandular-epithelial state of differentiation or progress through spontaneous transformation into highly invasive state.
Mutational analysis indicates that CAD cells differently regulate TH transcription depending on their state of differentiation.
Non-Hodgkin's lymphomas comprise a diverse group of diseases that are subclassified by the state of differentiation of the malignant B cells, presence of specific cytogenetic abnormalities, and characteristic morphology.
We detected differentiation markers (K14, K10 and involucrin) specific to the state of differentiation of keratinocytes [1].
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The culture was characterized by specific markers to describe the cell type, state of differentiation and functionality in comparison to the native tissue.
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