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"state of despair" is correct and usable in written English.
You can use it to refer to a situation where somebody is feeling very hopeless, overwhelmed, or despondent. For example, "After failing his driving test three times, Jack sunk into a state of despair."
Exact(59)
"Our house was sort of in a state of despair.
Butterworth looked on in a state of despair.
For several months she has withdrawn from the world in a state of despair.
The loss of their jungle has left them in a state of despair.
"Nobody can live in a perpetual state of despair," he said.
It's as if they're inhabiting a state of despair – and so are you, the viewer.
"I fought very hard to not end up in a state of despair.
"And no one wants to watch somebody in a perpetual state of despair".
Why did you want to write about this post-adolescent state of despair?
"They described being in an absolute state of despair, suicidal and still completely and utterly destroyed by the process".
Similar(1)
Animal studies have described a behavioral state of 'despair' or 'helplessness' consequent upon prenatal stress or lasting inescapable stressors [ 26, 27] that is related to neuroendocrine alterations [ 28].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com