Sentence examples for stat activity from inspiring English sources

Furthermore, a number of mechanisms, such as suppressors of cytokine signaling (SOCS) and the protein inhibitors of activated STATs (PIAS), also inhibit STAT activity as part of a negative feedback control mechanism [ 12, 14].

Recently we showed that PMT induces signal transducers and activators of transcription (STAT) activity through Gαq mediated activation of JAK kinases.

Using a 10xStatGFP reporter for STAT activation, we found that Asrij depletion caused a severe reduction in STAT activity, whereas overexpression increased STAT activity compared with controls.

Cytosolic localisation of staining was considered a measure for STAT expression whereas nuclear staining was considered indicative for STAT activity.

Of note, ganetespib treatment results in sustained depletion of JAK2, including the constitutively active JAK2V617F mutant, with subsequent loss of STAT activity and reduced STAT-target gene expression.

In addition to JAK-mediated signaling, activation of the RAS-MAPK pathway leads to the specific phosphorylation of a serine near the C-terminus of most STATs, and, while not required for STAT activity, this change may enhance STAT-mediated transcriptional activation [ 69].

Genetic and environmental factors might contribute to CRC aetiology and to the functional implications of STAT activities.

We find that multiple sensors of Jak-Stat activity detect strong activation of the Jak-Stat pathway within mutant cells and that this phenomenon is coincident with accumulation of the Upd receptor Dome in intracellular puncta in ept mutant cells that co-stain with the endosomal protein Hrs [31].

IL-1 suppresses IL-6-dependent Janus kinase-STAT activity and can block the induction by IL-6 of tissue inhibitor of metalloproteinase 1.

To test the relationship between ept and Jak-Stat activity further, two Stat92E reporter transgenes were placed in the background of ept mutations.

This antibody has been used in other studies of Drosophila Stat92E activity [7], [38], including one in which it was used to assess Jak-Stat activity in eyes discs mosaic for an allele of the ESCRT-II component vps25 [7].