Sentence examples similar to starting point for the structure from inspiring English sources

The ADC-7/BATSI complex provides insight into recognition of non-β-lactam inhibitors by ADC enzymes and offers a starting point for the structure-based optimization of this class of novel β-lactamase inhibitors against a key resistance target.

A posed model of cNPF1 within the binding site of EHD1-EH provides a clear rationale for the observed structure activity relationships within cNPF1 analogues and provides an excellent starting point for the structure-based design of additional cyclic peptide and small-molecule macrocycle inhibitors of EHD1-EH.

Seven compounds were selected as the starting point for the further structure modification in considering binding activity, synthesis difficulty, and structure similarity.

Lateral displacements' control of structures subjected to earthquake ground motion has now been recognized as a key factor in the assessment of system performance, leading to design approaches that use displacements rather than forces as the starting point for the seismic evaluation of structures.

Hit 1a was therefore used as starting point for the structure activity relationship (SAR) exploration and structure optimization for new BRAF inhibitors.

The following three characteristic temperatures are important in dam engineering: (1) The placing temperature Tp which is the starting point for the variation of temperature in a concrete structure.

Its member families were used as a starting point for the search for Bet v 1-related structures.

The structures described provide a starting point for the design and fabrication of complexed capsules made of two biocompatible natural polymers with potential applicability in medical or pharmaceutical applications.

Moreover, the structures served as the starting point for the engineering of IPK mutants capable of the chemoenzymatic synthesis of longer chain isoprenoid diphosphates from monophosphate precursors.

The structure of AHAS provides a starting point for the rational design of new herbicides.

One source of error could be that the mutations introduce larger conformational changes of the active site, changes which are not properly represented in our calculations because we use the WT crystal structure as a starting point for the mutant calculations.