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Exact(6)
The example below serves as a starting point for optimization.
Particularly substructures identified as important by our method might be a starting point for optimization of a lead compound.
The method also provides a starting point for optimization of large-scale production and purification of membrane proteins expressed in heterologous systems.
As a starting point for optimization, the procedure published in 2007 by Klein et al. [ 20] was used, as this study reported an identification rate of 35% of the LMW subproteome of Halobacterium salinarum.
Basic medium, which was used as the starting point for optimization of the culture conditions, contained 10 g/L glucose as the carbon source, 10 g/L peptone and 10 g/L yeast extract as the nitrogen source, and a mineral element component in the form of 2 g/L of K2HPO4; pH was adjusted to 6.0.
The procedure covered the 5-dimensional parameter space by a grid so as to find the best starting point for optimization.
Similar(54)
This chapter is presenting the various strategies used to find pertinent compounds as starting points for optimization up to a drug.
Repeating this process two more times gave us three new starting points for optimization with 54, 69 and 57 hits.
An alternative ligand discovery strategy is a fragment-based drug discovery, where low molecular weight compounds, known as fragments, are screened as initial starting points for optimization.
Together, the compounds 6 and 7 showed inhibitory potency on mPGES-1 activity in the low micromolar range, making them interesting starting points for optimization efforts.
In practice, we suggest that perturbation settings be chosen to ensure that the starting points for optimization of model parameters extend beyond the range of values that the data constrain the model to.
Related(19)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com