Sentence examples for starting point for further optimization from inspiring English sources

First, various homologs were compared to identify the most suitable starting point for further optimization.

This new scaffold can serve as a starting point for further optimization towards in vivo efficacy.

These results and compounds provide a starting point for further optimization, design, and synthesis of new antiviral agents for this (re)emerging disease.

The result, considered now simply as an arbitrary function on a time grid, is the starting point for further optimization with a gradient-based method that can quickly converge to high fidelities.

1H 15N chemical shift perturbation NMR was used to confirm the reversible binding and measure the dissociation constant of the most promising compound qualifying it as a high-quality starting point for further optimization.

Using the same strategy, an attempt was made to design and synthesize dimeric inhibitors with two neutral-P1 groups in hope to exploit the dimeric binding mode to achieve a starting point for further optimization.

We consider these achiral inhibitors highly suitable as starting points for further optimization.

The compounds 15 18 (MIC 11 29 μg/mL, 19 51 μM) can be used as starting points for further optimization.

Although the initial MESA development described here relied upon design-based methods, it is certainly possible that these functional designs may serve as starting points for further optimization using approaches such as directed evolution or computation-guided protein engineering.

In conclusion, using a novel α7/Ls-AChBP chimeric protein crystal structure we have successfully identified novel α7 receptor ligands that may serve as chemical starting points for further optimization.

Inhibitors 18 and 21 are also potent BMK1 inhibitors and possess favorable pharmacokinetic properties which enable their use as pharmacological probes of BMK1-dependent phenomena as well as starting points for further optimization efforts.