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Our data recognized that compound 6p could be considered as a starting point for development of new JmjC inhibitors.
The Imbricatolic acid and active derivatives in this study might represent a starting point for development of new potential PTP-1B inhibitors.
The natural product anacardic acid is a starting point for development of small molecule inhibitors of the histone acetyltransferase (HAT) p300/CBP associated factor (PCAF).
The novel chemical entities reported in this study could be used for overcoming the poor selectivity and low cellular activity of PTP1B inhibitors and might represent a starting point for development of therapeutic PTP inhibitors.
The development of the SisterTalk program could provide a useful starting point for development of successful weight control programs for black women in other parts of the United States as well as for other ethnic and racial groups.
Our results provide new insight into the mechanism of action of tumor suppressors and may be a starting point for development of new approaches to cancer treatment.
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In the past, their sequences were starting points for development of many peptide CCK-2R agonists.
We found new noncovalent inhibitors of PBPs which represent important starting points for development of more potent inhibitors of PBPs that can target penicillin-resistant bacteria.
Small molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents.
Moreover, many of the released structures are inhibitor complexes that offer chemical starting points for development of selective and potent inhibitors.
Accordingly, we undertook a high throughput screen (HTS) of 324 751 synthetic organic compounds against MarP itself in an effort to identify additional potential starting points for development of drugs that render Mtb vulnerable to conditions encountered in the host.
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