Sentence examples for starting peptide from inspiring English sources
The two-step evolutionary walk from R6A-1 to mGSP-1 resulted in an 8000-fold inversion in binding specificity, altered seven out of nine residues in the starting peptide core, and incorporated both positive and negative design steps.
Compared to our original starting peptide GNU7, hybrid peptides had an 8- to 32-fold improvement in antimicrobial activity against Gram-negative bacteria, such as Escherichia coli and Salmonella typhimurium.
These conditions ensured maximum alkylation of the starting peptide with minimal side product (e.g., dialkylation) formation.
Chromatographic analysis and purification of the starting peptide (5; Scheme 1) was performed on a Dionex Ultimate 300 HPLC system (Dionex Corp).
Significantly, the predominant product in samples of the H3 Lysine-9(Me/ iPr) peptide with JMJD2E possessed a mass 16 Da higher than the starting peptide, implying hydroxylation.
The most prominent ion in the MS spectrum is at m/ z 421.8; this mass corresponds to the [M + 2H]2+ ion of the starting peptide and results from fragmentation of the amide bond involving the lysine side chain.
Related digestion tables in the Protein record view include enzymes used for digestion, protein IDs that contain the particular peptide, starting position of the peptide in the protein sequence, level of digestion and enzyme and peptide sequence used in the previous (Parent) digestion.
Fmoc-S-RAM TentaGel (Rapp Polymere, Tübingen, Germany) resin was used to start the peptide assembly.
In a first in silico test, we show that by simultaneously optimizing the sequence and structure of three to nine residue peptide extensions starting from short (1 6 residue) peptide stubs in the binding pocket of a peptide binding protein, the approach can recover both the conformations and the sequences of known binding peptides.
Since the amino group on lysine amino acid could be easily modified, we synthesized azido-functionalized cyclo RGDfK) peptide starting from Fmoc-Gly-2Cl-Trt resin using standard Fmoc solid-phase peptide synthesis chemistry.
The class III signal peptide starts with a leader peptide containing a majority of hydrophilic and neutral residues, whose length varies between 6 and 26 amino acids (aa) in P. aeruginosa PilA (Paranchych et al., 1979) and A. actinomycetemcomitans Flp1 (Kachlany et al., 2001), respectively.
